Imaging synaptic density: the next holy grail of neuroscience?

ME Serrano, E Kim, MM Petrinovic… - Frontiers in …, 2022 - frontiersin.org
The brain is the central and most complex organ in the nervous system, comprising billions
of neurons that constantly communicate through trillions of connections called synapses …

Synaptic vesicle glycoprotein 2A: features and functions

R Rossi, S Arjmand, SL Bærentzen, A Gjedde… - Frontiers in …, 2022 - frontiersin.org
In recent years, the field of neuroimaging dramatically moved forward by means of the
expeditious development of specific radioligands of novel targets. Among these targets, the …

Imaging of synaptic density in neurodegenerative disorders

RE Carson, M Naganawa, T Toyonaga… - Journal of Nuclear …, 2022 - Soc Nuclear Med
PET technology has produced many radiopharmaceuticals that target specific brain proteins
and other measures of brain function. Recently, a new approach has emerged to image …

[HTML][HTML] PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats

MB Thomsen, SA Ferreira, AC Schacht… - Neurobiology of …, 2021 - Elsevier
Abstract Alpha-synuclein (a-syn) can aggregate and form toxic oligomers and insoluble
fibrils which are the main component of Lewy bodies. Intra-neuronal Lewy bodies are a …

PET imaging of synaptic density in Parkinsonian disorders

SL Martin, C Uribe, AP Strafella - Journal of Neuroscience …, 2024 - Wiley Online Library
Synaptic dysfunction and altered synaptic pruning are present in people with Parkinsonian
disorders. Dopamine loss and alpha‐synuclein accumulation, two hallmarks of Parkinson's …

[HTML][HTML] Exercise protects synaptic density in a rat model of Parkinson's disease

KH Binda, TP Lillethorup, CC Real, SL Bærentzen… - Experimental …, 2021 - Elsevier
Background Parkinson's disease (PD) is characterized by Lewy body and neurite pathology
associated with dopamine terminal dysfunction. Clinically, it is associated with motor …

[HTML][HTML] In vivo imaging of synaptic density with [11C] UCB-J PET in two mouse models of neurodegenerative disease

M Xiong, S Roshanbin, J Rokka, E Schlein… - Neuroimage, 2021 - Elsevier
The positron emission tomography (PET) radioligand [11 C] UCB-J binds to synaptic vesicle
protein 2A (SV2A) and is used to investigate synaptic density in the living brain. Clinical …

[HTML][HTML] Synaptic density and neuronal metabolic function measured by positron emission tomography in the unilateral 6-OHDA rat model of Parkinson's disease

NR Raval, F Gudmundsen, M Juhl… - Frontiers in synaptic …, 2021 - frontiersin.org
Parkinson's disease (PD) is caused by progressive neurodegeneration and characterised by
motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations …

An overview: Radiotracers and nano-radiopharmaceuticals for diagnosis of Parkinson's disease

N Ozolmez, M Silindir-Gunay… - Applied Radiation and …, 2023 - Elsevier
Parkinson's disease (PD) is a widespread progressive neurodegenerative disease. Clinical
diagnosis approaches are insufficient to provide an early and accurate diagnosis before a …

[HTML][HTML] PET imaging in animal models of Parkinson's disease

R Ni - Behavioural Brain Research, 2023 - Elsevier
Alpha-synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies and
multiple system atrophy, are characterized by aberrant accumulation of alpha-synuclein and …