Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …

Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and
through the brain transports not only those water-like fluids but also any solutes they carry …

The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …

Cerebral amyloid angiopathy (CAA) is a common disease in older adults that contributes to
dementia,–. In CAA, amyloid beta (Aβ) is deposited along either capillaries (type 1) or vessel …

Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia, whilst
Parkinson's disease (PD) is a neurodegenerative movement disorder. These two …

High-altitude cerebral edema (HACE) and acute mountain sickness (AMS) are
neuropathologies associated with rapid exposure to hypoxia. However, speculation remains …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with high prevalence
rate among the elderly population. A large number of clinical studies have suggested …

Cerebrospinal fluid (CSF), predominantly produced in the ventricles and circulating
throughout the brain and spinal cord, is a key protective mechanism of the central nervous …

The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …