[HTML][HTML] A new era of macrophage-based cell therapy
Macrophages are essential innate immune cells found throughout the body that have
protective and pathogenic functions in many diseases. When activated, macrophages can …
protective and pathogenic functions in many diseases. When activated, macrophages can …
[HTML][HTML] Current and future concepts for the generation and application of genetically engineered CAR-T and TCR-T cells
M Hiltensperger, AM Krackhardt - Frontiers in Immunology, 2023 - frontiersin.org
Adoptive cell therapy (ACT) has seen a steep rise of new therapeutic approaches in its
immune-oncology pipeline over the last years. This is in great part due to the recent …
immune-oncology pipeline over the last years. This is in great part due to the recent …
CD19 CAR antigen engagement mechanisms and affinity tuning
Chimeric antigen receptor (CAR) T cell therapy relies on T cells that are guided by synthetic
receptors to target and lyse cancer cells. CARs bind to cell surface antigens through an scFv …
receptors to target and lyse cancer cells. CARs bind to cell surface antigens through an scFv …
Programmed Remodeling of the Tumor Milieu to Enhance NK Cell Immunotherapy Combined with Chemotherapy for Pancreatic Cancer
X Yang, C Li, H Yang, T Li, S Ling, Y Zhang, F Wu… - Nano Letters, 2024 - ACS Publications
Natural killer (NK) cell-based adoptive immunotherapy has demonstrated encouraging
therapeutic effects in clinical trials for hematological cancers. However, the effectiveness of …
therapeutic effects in clinical trials for hematological cancers. However, the effectiveness of …
[HTML][HTML] Emerging trends in immunotherapy for cancer
Recent advances in cancer immunology have enabled the discovery of promising
immunotherapies for various malignancies that have shifted the cancer treatment paradigm …
immunotherapies for various malignancies that have shifted the cancer treatment paradigm …
[HTML][HTML] Biomaterials-mediated engineering of the immune system
C Backlund, S Jalili-Firoozinezhad… - Annual review of …, 2023 - annualreviews.org
Modulation of the immune system is an important therapeutic strategy in a wide range of
diseases, and is fundamental to the development of vaccines. However, optimally safe and …
diseases, and is fundamental to the development of vaccines. However, optimally safe and …
[HTML][HTML] Breakthroughs in cancer immunotherapy: an overview of T cell, NK cell, Mφ, and DC-based treatments
S Lee, TD Kim - International Journal of Molecular Sciences, 2023 - mdpi.com
Efforts to treat cancer using chimeric antigen receptor (CAR)-T therapy have made
astonishing progress and clinical trials against hematopoietic malignancies have …
astonishing progress and clinical trials against hematopoietic malignancies have …
[HTML][HTML] The role of macrophages-mediated communications among cell compositions of tumor microenvironment in cancer progression
M Li, P Jiang, S Wei, J Wang, C Li - Frontiers in Immunology, 2023 - frontiersin.org
Recent studies have revealed that tumor-associated macrophages are the most abundant
stromal cells in the tumor microenvironment and play an important role in tumor initiation …
stromal cells in the tumor microenvironment and play an important role in tumor initiation …
[HTML][HTML] A systematic framework for predictive biomarkers in immune effector cell-associated neurotoxicity syndrome
OH Butt, AY Zhou, BM Ances, JF DiPersio… - Frontiers in …, 2023 - frontiersin.org
Chimeric antigen receptor (CAR)-T cell therapy has revolutionized the management of
several life-threatening malignancies, often achieving durable sustained responses. The …
several life-threatening malignancies, often achieving durable sustained responses. The …
[HTML][HTML] Fully closed cell sorter for immune cell therapy manufacturing
M Matsumoto, S Tashiro, T Ito, K Takahashi… - … Therapy-Methods & …, 2023 - cell.com
By analyzing patients treated with adoptive immune cell therapies, various immune cell
phenotypes have been found in the starting and infused materials as determinants of …
phenotypes have been found in the starting and infused materials as determinants of …