Curcumin is a constituent (up to∼ 5%) of the traditional medicine known as turmeric. Interest
in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led …

Over the past decade, covalent kinase inhibitors (CKI) have seen a resurgence in drug
discovery. Covalency affords a unique set of advantages as well as challenges relative to …

Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …

Curcumin, the dietary polyphenol isolated from Curcuma longa (turmeric), is commonly used
as an herb and spice worldwide. Because of its bio-pharmacological effects curcumin is also …

Alzheimer's disease (AD) is the most common type of senile dementia, characterized by
neurofibrillary tangle and amyloid plaque in brain pathology. Major efforts in AD drug were …

Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly. As the prevalence
of AD rises in the 21st century, there is an urgent need for the development of effective …

Alzheimer's disease (AD) is a multifactorial syndrome resulting in profound misery and
poses a substantial burden on human health, economy, and society throughout the world …

Abstract Chalcone [(E)-1, 3-diphenyl-2-propene-1-one], a small molecule with α, β
unsaturated carbonyl group is a precursor or component of many natural flavonoids and …

Curcumin is a polyphenolic natural compound with diverse and attractive biological
properties, which may prevent or ameliorate pathological processes underlying age-related …

Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases
have multifaceted nature because of the different factors contributing to their progression …