The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas

OH Petersen, JV Gerasimenko… - Physiological …, 2021 - journals.physiology.org
This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

Severe acute pancreatitis: surgical indications and treatment

M Heckler, T Hackert, K Hu, CM Halloran… - … archives of surgery, 2021 - Springer
Background Acute pancreatitis (AP) is defined as an acute inflammatory attack of the
pancreas of sudden onset. Around 25% of patients have either moderately severe or severe …

[HTML][HTML] TRPM2 channel-mediated cell death: An important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions

P Malko, LH Jiang - Redox biology, 2020 - Elsevier
Oxidative stress resulting from the accumulation of high levels of reactive oxygen species is
a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One …

Antibiotic utilization in acute pancreatitis: a narrative review

A Severino, S Varca, C Airola, T Mezza, A Gasbarrini… - Antibiotics, 2023 - mdpi.com
Acute pancreatitis is a complex inflammatory disease with significant morbidity and mortality.
Despite advances in its management, the role of antibiotics in the prophylaxis and treatment …

Ruthenium red attenuates acute pancreatitis by inhibiting MCU and improving mitochondrial function

X Yu, C Dai, X Zhao, Q Huang, X He, R Zhang… - Biochemical and …, 2022 - Elsevier
Acute pancreatitis (AP) is a common inflammatory disease of the digestive system.
Mitochondrial calcium uniporter (MCU) mediates mitochondrial uptake of Ca 2+ and plays …

[HTML][HTML] Orai1 calcium channel inhibition prevents progression of chronic pancreatitis

V Szabó, N Csákány-Papp, M Görög, T Madácsy… - JCI insight, 2023 - ncbi.nlm.nih.gov
Patients with recurrent acute pancreatitis (RAP) are at significant risk of developing early
chronic pancreatitis (CP), which progresses into irreversible, end-stage CP with severe …

Trends and recent developments in pharmacotherapy of acute pancreatitis

J Hey-Hadavi, P Velisetty, S Mhatre - Postgraduate Medicine, 2023 - Taylor & Francis
Acute pancreatitis (AP), a complex inflammatory disease of the pancreas, is associated with
increased morbidity and mortality. Currently, no specific therapies are approved for its …

SARS-CoV-2 S Protein Subunit 1 Elicits Ca2+ Influx – Dependent Ca2+ Signals in Pancreatic Stellate Cells and Macrophages In Situ

JV Gerasimenko, OH Petersen, OV Gerasimenko - Function, 2022 - academic.oup.com
The S protein subunit 1 (S1) of SARS-CoV-2 is known to be responsible for the binding of
the virus to host cell receptors, but the initial intracellular signalling steps following receptor …

High Triglyceride–Glucose Index Is Associated with Poor Prognosis in Patients with Acute Pancreatitis

Y Wei, J Guo - Digestive Diseases and Sciences, 2023 - Springer
Background Acute pancreatitis (AP) is a common gastrointestinal disease worldwide.
Severe acute pancreatitis (SAP) is characterized as persistent organ failure with a mortality …

Systemic bile acids affect the severity of acute pancreatitis in mice depending on their hydrophobicity and the disease pathogenesis

QT Tran, M Sendler, ML Wiese, J Doller… - International Journal of …, 2022 - mdpi.com
Acute pancreatitis (AP) is a major, globally increasing gastrointestinal disease and a biliary
origin is the most common cause. However, the effects of bile acids (BAs), given …