Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5–2% of
the population worldwide. The disease is characterized by the selective loss of melanocytes …

CD8+ T cells are critical mediators of cytotoxic effector function in infection, cancer and
autoimmunity. In cancer and chronic viral infection, CD8+ T cells undergo a progressive loss …

Vitiligo is a multifactorial reversible skin disorder characterized by distinct white patches that
result from melanocyte destruction. Activated CXCR3+ CD8+ T cells promote melanocyte …

Vitiligo is an autoimmune depigment disease results from extensive melanocytes
destruction. The destruction of melanocyte is thought to be of multifactorial causation …

Vitiligo is the most common depigmenting disorder affecting 0.1%–2% of the population
worldwide. The characteristic white patches result from the selective loss of melanocytes …

Vitiligo is an autoimmune disease of the skin that targets pigment-producing melanocytes
and results in patches of depigmentation that are visible as white spots. Recent research …

Therapeutic options for autoimmune diseases typically consist of broad and targeted
immunosuppressive agents. However, sustained clinical benefit is rarely achieved, as the …

Vitiligo is an autoimmune disease of the skin mediated by CD8+ T cells that kill melanocytes
and create white spots. Skin lesions in vitiligo frequently return after discontinuing …

Chemokines and their receptors play an important role in the recruitment, activation and
differentiation of immune cells. The chemokine receptor, CXCR3, and its ligands, CXCL9 …

Tissue resident memory T (T RM) cells reside in peripheral, non-lymphoid tissues such as
the skin, where they act as alarm-sensor cells or cytotoxic cells. Physiologically, skin T RM …