Multi-functional antibody profiling for malaria vaccine development and evaluation
Introduction A vaccine would greatly accelerate current global efforts toward malaria
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …
Repetitive sequences in malaria parasite proteins
HM Davies, SD Nofal, EJ McLaughlin… - FEMS microbiology …, 2017 - academic.oup.com
Five species of parasite cause malaria in humans with the most severe disease caused by
Plasmodium falciparum. Many of the proteins encoded in the P. falciparum genome are …
Plasmodium falciparum. Many of the proteins encoded in the P. falciparum genome are …
The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites
Malaria is caused by five different Plasmodium spp. in humans each of which modifies the
host erythrocyte to survive and replicate. The two main causes of malaria, P. falciparum and …
host erythrocyte to survive and replicate. The two main causes of malaria, P. falciparum and …
Antibody Targets on the Surface of Plasmodium falciparum–Infected Erythrocytes That Are Associated With Immunity to Severe Malaria in Young Children
Abstract Background Sequestration of Plasmodium falciparum–infected erythrocytes (IEs) in
the microvasculature contributes to pathogenesis of severe malaria in children. This …
the microvasculature contributes to pathogenesis of severe malaria in children. This …
Plasmodium falciparum PfEMP1 modulates monocyte/macrophage transcription factor activation and cytokine and chemokine responses
NG Sampaio, EM Eriksson, L Schofield - Infection and immunity, 2018 - Am Soc Microbiol
Immunity to Plasmodium falciparum malaria is slow to develop, and it is often asserted that
malaria suppresses host immunity, although this is poorly understood and the molecular …
malaria suppresses host immunity, although this is poorly understood and the molecular …
Declining Malaria Transmission Differentially Impacts the Maintenance of Humoral Immunity to Plasmodium falciparum in Children
CK Mugyenyi, SR Elliott, XZ Yap, G Feng… - The Journal of …, 2017 - academic.oup.com
Background We investigated the poorly understood impact of declining malaria transmission
on maintenance of antibodies to Plasmodium falciparum merozoite antigens and infected …
on maintenance of antibodies to Plasmodium falciparum merozoite antigens and infected …
Reduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women
Background The pathogenesis of malaria in pregnancy (MiP) involves accumulation of P.
falciparum-infected red blood cells (pRBCs) in the placenta, contributing to poor pregnancy …
falciparum-infected red blood cells (pRBCs) in the placenta, contributing to poor pregnancy …
The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children
Background Antibodies targeting malaria blood-stage antigens are important targets of
naturally acquired immunity, and may act as valuable biomarkers of malaria exposure …
naturally acquired immunity, and may act as valuable biomarkers of malaria exposure …
Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis
In malaria, rosetting is described as a phenomenon where an infected erythrocyte (IRBC) is
attached to uninfected erythrocytes (URBC). In some studies, rosetting has been associated …
attached to uninfected erythrocytes (URBC). In some studies, rosetting has been associated …
Acquisition of Antibodies Against Endothelial Protein C Receptor–Binding Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with …
JS Rambhatla, L Turner, L Manning… - The Journal of …, 2019 - academic.oup.com
Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates
parasite sequestration in postcapillary venules in P. falciparum malaria. PfEMP1 types can …
parasite sequestration in postcapillary venules in P. falciparum malaria. PfEMP1 types can …