There are numerous theories of aging, a process which still seems inevitable. Aging leads to
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …

Fetal life is characterized by a tremendous plasticity and ability to respond to various
environmental and lifestyle factors, including maternal nutrition. Identification of the role of …

Composed of hundreds of microbial species, the composition of the human gut microbiota
can vary with chronic diseases underlying health disparities that disproportionally affect …

Metabolites derived from dietary choline and l-carnitine, such as trimethylamine N-oxide and
betaine, have recently been identified as novel risk factors for atherosclerosis in mice and …

Idiopathic juxtafoveal retinal telangiectasis type 2 (macular telangiectasia type 2; MacTel) is
a rare neurovascular degenerative retinal disease. To identify genetic susceptibility loci for …

Sex differences in incidence and prevalence of and morbidity and mortality from
cardiovascular disease are well documented. However, many studies examining the genetic …

Sex differences in coronary artery disease (CAD) presentation, risk factors and prognosis
have been widely studied. Similarly, studies on atherosclerosis have shown prominent sex …

Genetic or nutritional deficiencies in homocysteine (Hcy) metabolism lead to
hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of …

Background One of the fascinating aspects of epigenetic regulation is that it provides means
to rapidly adapt to environmental change. This is particularly relevant in the plant kingdom …

Observational studies consistently reported an association between plasma total
homocysteine concentrations and the risk of vascular events. In contrast, data from …