One of the characteristic hallmarks of Alzheimer's disease (AD) is an accumulation of
amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the …

Neprilysin has a major role in both the generation and degradation of bioactive peptides.
LCZ696 (valsartan/sacubitril, Entresto), the first of the new ARNI (dual-acting angiotensin …

A pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-β (Aβ)
protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD …

Silver nanoparticles (AgNPs) have antibacterial characteristics, and currently are applied in
Ag-containing products. This study found neural cells can uptake 3–5 nm AgNPs, and …

The pathomechanism of Alzheimer's disease (AD) certainly involves mitochondrial
disturbances, glutamate excitotoxicity, and neuroinflammation. The three main aspects of …

This review examines the role of impaired amyloid-β clearance in the accumulation of
amyloid-β in the brain and the periphery, which is closely associated with Alzheimer's …

Alzheimer's disease (AD) is the most common form of dementia. The accumulation of β-
amyloid plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau protein …

Alzheimer's disease (AD) is a major problem of health and disability, with a relevant
economic impact on our society. Despite important advances in pathogenesis, diagnosis …

Alzheimer's disease (AD) is a neurodegenerative process primarily characterized by
amyloid-β (Aβ) agglomeration, neuroinflammation, and cognitive dysfunction. The prominent …

Age-related neurodegenerative disorders such as Alzheimer's disease (AD) have become a
critical public health issue due to the significantly extended human lifespan, leading to …