Originally isolated from bone marrow, mesenchymal stromal cells (MSCs) have since been
obtained from various fetal and post-natal tissues and are the focus of an increasing number …

Cryopreservation is the application of low temperatures to preserve the structural and
functional integrity of cells and tissues. Conventional cooling protocols allow ice to form and …

Cryoprotectants (CPAs) are critical to successful cryopreservation because they can protect
cells from cryoinjuries. Because of the limitations of current CPAs, especially the toxicity, the …

Cell cryopreservation maintains cellular life at sub‐zero temperatures by slowing down
biochemical processes. Various cell types are routinely cryopreserved in modern …

The continuous discovery of human mesenchymal stem cells (hMSCs) in different tissues is
stirring up a tremendous interest as a cell source for regenerative medicine therapies …

Dimethylsufoxide (DMSO) being universally used as a cryoprotectant in clinical adoptive cell-
therapy settings to treat hematological malignancies and solid tumors is a growing concern …

Human pluripotent stem cell (hPSC)-derived cell therapy requires production of therapeutic
cells in large quantity, which starts from thawing the cryopreserved cells from a working cell …

The compatible solutes ectoine and hydroxyectoine are widely produced by bacteria as
protectants against osmotic and temperature stress. l-Aspartate-beta-semialdehyde is used …

The ability to cryopreserve natural killer (NK) cells has a significant potential in modern
cancer immunotherapy. Current cryopreservation protocols cause deterioration in NK cell …

Cell/tissue biopreservation has broad public health and socio-economic impact affecting
millions of lives. Cryopreservation technologies provide an efficient way to preserve cells …