Prothrombin complex concentrates (PCCs) are used mainly for emergency reversal of
vitamin K antagonist therapy. Historically, the major drawback with PCCs has been the risk …

Severe trauma-related bleeding is associated with high mortality. Standard coagulation tests
provide limited information on the underlying coagulation disorder. Whole-blood viscoelastic …

Backround—Physicians reverse patients' warfarin anticoagulation with frozen plasma or
prothrombin complex concentrate. Our objective was to determine adverse event frequency …

Modern four‐factor prothrombin complex concentrate was designed originally for rapid
targeted replacement of the coagulation factors II, VII, IX and X. Dosing strategies for the …

Despite increasing use of prothrombin complex concentrate (PCC) to treat hemorrhage-
associated coagulopathy, few studies have investigated PCC in trauma, and there is a …

Background Prothrombin complex concentrate (PCC) has recently emerged as an effective
alternative to fresh frozen plasma (FFP) in treating excessive perioperative bleeding. This …

BACKGROUND: Administration of coagulation factor concentrates to treat bleeding after
cardiac surgery with cardiopulmonary bypass might be a strategy for reducing allogeneic …

Background In patients with cirrhosis, the synthesis of coagulation factors can fall short,
reflected by a prolonged prothrombin time. Although anticoagulants factors are decreased …

Background Treatment with vitamin K antagonists is associated with increased morbidity
and mortality. Reversal therapy with prothrombin complex concentrate (PCC) is used …

The early and aggressive high-volume administration of fresh frozen plasma, platelet
concentrates, and red blood cells (RBCs), using ratio-driven massive transfusion protocols …