[HTML][HTML] Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

H Sies - Redox biology, 2017 - Elsevier
Hydrogen peroxide emerged as major redox metabolite operative in redox sensing,
signaling and redox regulation. Generation, transport and capture of H 2 O 2 in biological …

Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks

EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

[HTML][HTML] Ultrasensitive genetically encoded indicator for hydrogen peroxide identifies roles for the oxidant in cell migration and mitochondrial function

VV Pak, D Ezeriņa, OG Lyublinskaya, B Pedre… - Cell metabolism, 2020 - cell.com
Summary Hydrogen peroxide (H 2 O 2) is a key redox intermediate generated within cells.
Existing probes for H 2 O 2 have not solved the problem of detection of the ultra-low …

Hydrogen peroxide metabolism and functions in plants

N Smirnoff, D Arnaud - New phytologist, 2019 - Wiley Online Library
Contents Summary 1197 I. Introduction 1198 II. Measurement and imaging of H2O2 1198 III.
H2O2 and O2·− toxicity 1199 IV. Production of H2O2: enzymes and subcellular locations …

Photosynthesis-dependent H2O2 transfer from chloroplasts to nuclei provides a high-light signalling mechanism

M Exposito-Rodriguez, PP Laissue… - Nature …, 2017 - nature.com
Chloroplasts communicate information by signalling to nuclei during acclimation to
fluctuating light. Several potential operating signals originating from chloroplasts have been …

The fluorescent protein sensor roGFP2‐Orp1 monitors in vivo H2O2 and thiol redox integration and elucidates intracellular H2O2 dynamics during elicitor‐induced …

T Nietzel, M Elsässer, C Ruberti, J Steinbeck… - New …, 2019 - Wiley Online Library
Summary Hydrogen peroxide (H2O2) is ubiquitous in cells and at the centre of
developmental programmes and environmental responses. Its chemistry in cells makes …

Circularly permuted fluorescent protein-based indicators: history, principles, and classification

AI Kostyuk, AD Demidovich, DA Kotova… - International journal of …, 2019 - mdpi.com
Genetically encoded biosensors based on fluorescent proteins (FPs) are a reliable tool for
studying the various biological processes in living systems. The circular permutation of …

Chemotherapy with cisplatin: insights into intracellular pH and metabolic landscape of cancer cells in vitro and in vivo

MV Shirmanova, IN Druzhkova, MM Lukina… - Scientific reports, 2017 - nature.com
Although cisplatin plays a central role in cancer chemotherapy, the mechanisms of cell
response to this drug have been unexplored. The present study demonstrates the …

Oxidative stress from environmental exposures

JM Samet, PA Wages - Current opinion in toxicology, 2018 - Elsevier
Oxidative stress is arguably the most common mechanism in the toxicology of environmental
agents, unifying the action of broad classes of physichochemically disparate environmental …

Recent advances in cancer metabolism: a technological perspective

YP Kang, NP Ward, GM DeNicola - Experimental & molecular medicine, 2018 - nature.com
Cancer cells are highly dependent on metabolic pathways to sustain both their proliferation
and adaption to harsh microenvironments. Thus, understanding the metabolic …