Strong xenorejection limits the clinical application of porcine islet transplantation in type 1
diabetes. Targeting T cell-mediated rejection is one of the main approaches to improve long …

Neonatal porcine islets-like clusters (NPICCs) are a promising source for cell therapy of type
1 diabetes. Freshly isolated NPICCs are composed of progenitor cells and endocrine cells …

Immune rejection presents a significant challenge in xenogenic meniscal transplantation.
Pigs are widely regarded as an advantageous tissue source for such transplants, with …

Cultured autologous human articular chondrocyte (HAC) implantation has been extensively
investigated for safe and effective promotion of structural and functional restoration of knee …

Cytotherapies are often necessary for the management of symptomatic large knee (osteo)-
chondral defects. While autologous chondrocyte implantation (ACI) has been clinically used …

Background Human-treated dentin matrix (hTDM) has recently been studied as a natural
extracellular matrix-based biomaterial for dentin pulp regeneration. However, porcine …

The vascular endothelium of xenografted pig organs represents the initial site of rejection
after exposure to recipient immune cells. In this study, we aimed to develop a promoter …

Definition Primary chondroprogenitors obtained from standardized cell sources (eg, FE002
clinical grade cell sources) may be cultured in vitro and may be cytotherapeutically applied …

Articular cartilage lacks the ability to repair itself because it is devoid of blood vessels,
nerves, and lymph, and there is no effective treatment that contributes to the cartilage repair …

Articular cartilage lacks the ability to repair itself because it is devoid of blood vessels,
nerves, and lymph, and there is no effective treatment that contributes to the cartilage repair …