Kidney involvement in patients with systemic lupus erythematosus—lupus nephritis (LN)—is
one of the most important and common clinical manifestations of this disease and occurs in …

Through their potential pro-fibrotic and pro-inflammatory properties, macrophages are at the
cross-road of key SSc pathogenic processes and associated manifestations. Investigative …

Extracellular DNA trap formation is a cellular function of neutrophils, eosinophils, and
basophils that facilitates the immobilization and killing of invading microorganisms in the …

Autoantibodies are well known as potentially highly harmful antibodies which attack the host
via binding to self-antigens, thus causing severe associated diseases and symptoms (eg …

Severe forms of pulmonary arterial hypertension (PAH) are most frequently the
consequence of a lumen-obliterating angiopathy. One pathobiological model is that the …

The integrity of the genome is under constant threat of environmental and endogenous
agents that cause DNA damage. Endogenous damage is particularly pervasive, occurring at …

Recent studies have illustrated the functional significance of DNA recognition in the
activation of innate immune responses among a variety of diseases. The cyclic GMP-AMP …

There is a considerable unmet demand for safe and efficacious medications in the realm of
autoimmune and inflammatory diseases. The fate of the immune cells is precisely governed …

The recognition that cytosolic mitochondrial DNA (mtDNA) activates cyclic GMP–AMP
synthase-stimulator of interferon genes (cGAS-STING) innate immune signaling has …

Regulatory T (Treg) cells are essential for maintaining self-immune tolerance. Reduced
numbers or functions of Treg cells have been involved in the pathogenesis of various …