Applications of biosensors in Alzheimer's disease diagnosis

LC Brazaca, I Sampaio, V Zucolotto, BC Janegitz - Talanta, 2020 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
and irreversible cognitive decline. Currently, it affects 36 million people and due to …

Microglial activation and tau propagate jointly across Braak stages

TA Pascoal, AL Benedet, NJ Ashton, MS Kang… - Nature medicine, 2021 - nature.com
Compelling experimental evidence suggests that microglial activation is involved in the
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …

18F-MK-6240 PET for early and late detection of neurofibrillary tangles

TA Pascoal, J Therriault, AL Benedet, M Savard… - Brain, 2020 - academic.oup.com
Braak stages of tau neurofibrillary tangle accumulation have been incorporated in the
criteria for the neuropathological diagnosis of Alzheimer's disease. It is expected that Braak …

Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease

NJ Ashton, AL Benedet, TA Pascoal, TK Karikari… - …, 2022 - thelancet.com
Background Phosphorylated tau (p-tau) epitopes in cerebrospinal fluid (CSF) are accurate
biomarkers for a pathological and clinical diagnosis of Alzheimer's disease (AD) and are …

3D-deep learning based automatic diagnosis of Alzheimer's disease with joint MMSE prediction using resting-state fMRI

NT Duc, S Ryu, MNI Qureshi, M Choi, KH Lee, B Lee - Neuroinformatics, 2020 - Springer
We performed this research to 1) evaluate a novel deep learning method for the diagnosis of
Alzheimer's disease (AD) and 2) jointly predict the Mini Mental State Examination (MMSE) …

Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages

TA Pascoal, AL Benedet, DL Tudorascu, J Therriault… - Brain, 2021 - academic.oup.com
Tracking longitudinal tau tangles accumulation across the Alzheimer's disease continuum is
crucial to better understand the natural history of tau pathology and for clinical trials …

Alzheimer's disease and Parkinson's disease: a nutritional toxicology perspective of the impact of oxidative stress, mitochondrial dysfunction, nutrigenomics and …

A Agnihotri, OI Aruoma - Journal of the American College of …, 2020 - Taylor & Francis
Introduction: Alzheimer's disease is primarily a dementia-related disorder from progressive
cognitive deterioration and memory impairment, while Parkinson's disease is primarily a …

Single and combined neuroimaging techniques for Alzheimer's disease detection

M Amini, MM Pedram, A Moradi… - Computational …, 2021 - Wiley Online Library
Alzheimer's disease (AD) consists of the gradual process of decreasing volume and quality
of neuron connection in the brain, which consists of gradual synaptic integrity and loss of …

A cross-scanner and cross-tracer deep learning method for the recovery of standard-dose imaging quality from low-dose PET

S Xue, R Guo, KP Bohn, J Matzke, M Viscione… - European journal of …, 2022 - Springer
Purpose A critical bottleneck for the credibility of artificial intelligence (AI) is replicating the
results in the diversity of clinical practice. We aimed to develop an AI that can be …

Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly

AR Kamer, S Pushalkar, D Gulivindala… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Periodontal disease is a chronic, inflammatory bacterial dysbiosis that is
associated with both Alzheimer's disease (AD) and Down syndrome. Methods A total of 48 …