The biogenesis and functions of piRNAs in human diseases

X Wu, Y Pan, Y Fang, J Zhang, M Xie, F Yang… - … Therapy-Nucleic Acids, 2020 - cell.com
Piwi-interacting RNAs (piRNAs) are a novel type of small noncoding RNAs, which are 26–30
nt in length and bind to Piwi proteins. These short RNAs were originally discovered in …

piR-823 tale as emerging cancer-hallmark molecular marker in different cancer types: a step-toward ncRNA-precision

FH Shaker, EF Sanad, H Elghazaly, SM Hsia… - Naunyn-Schmiedeberg's …, 2024 - Springer
PIWI-interacting RNAs (piRNAs) have received a lot of attention for their functions in cancer
research. This class of short non-coding RNAs (ncRNA) has roles in genomic stability …

piRSNP: A Database of piRNA-related SNPs and their Effects on Cancerrelated piRNA Functions

Y Liu, A Li, Y Zhu, X Pang, X Hei, G Xie… - Current …, 2023 - ingentaconnect.com
Background: PIWI-interacting RNAs (piRNAs) are a kind of small non-coding RNAs which
interact with PIWI proteins and play a vital role in safeguarding genome. Single nucleotide …

[HTML][HTML] A comprehensive review on the role of PIWI-interacting RNA (piRNA) in gynecological cancers

BJ Silvia, S Shetty, R Behera, A Khandelwal, M Gore… - Life Sciences, 2024 - Elsevier
Gynecological cancers are currently a major public health concern due to increase in
incidence and mortality globally. PIWI-interacting RNA (piRNA) are small non-coding RNA …

PIWI-interacting RNAs are differentially expressed during cardiac differentiation of human pluripotent stem cells

A La Greca, MA Scarafía, MC Hernández Cañás… - PloS one, 2020 - journals.plos.org
PIWI-interacting RNAs (piRNAs) are a class of non-coding RNAs initially thought to be
restricted exclusively to germline cells. In recent years, accumulating evidence has …

PiRNA hsa_piR_019914 promoted chondrocyte anabolic metabolism By inhibiting LDHA-dependent ROS production

YX Gao, W Yan, L Sun, XL Zhang - Cartilage, 2024 - journals.sagepub.com
Objectives Osteoarthritis (OA) is the most common joint disease. The occurrence and
progression of OA are regulated by epigenetics. A large number of studies have shown the …

Transposable elements and Piwi-interacting RNAs in hemato-oncology with a focus on myelodysplastic syndrome

MD Merkerova, Z Krejcik - International Journal of …, 2021 - spandidos-publications.com
Our current understanding of hematopoietic stem cell differentiation and the abnormalities
that lead to leukemogenesis originates from the accumulation of knowledge regarding …

Daphnia magna egg piRNA cluster expression profiles change as mothers age

J Hearn, TJ Little - BMC genomics, 2022 - Springer
Background PiRNAs prevent transposable elements wreaking havoc on the germline
genome. Changes in piRNA expression over the lifetime of an individual may impact on …

Prediction of cancer-related piRNAs based on network-based stratification analysis

Y Liu, G Xie, A Li, Z He, X Hei - International Journal of Pattern …, 2022 - World Scientific
PIWI-interacting RNA (PiRNA) was discovered in 2006 and is expected to become a new
biomarker for diagnosis and prognosis of various diseases. The purpose of this study is to …

piRNA-Based Cancer Therapy in Hypoxic Tumor

SK Ray, S Mukherjee - Hypoxia in Cancer: Significance and Impact on …, 2023 - Springer
Tumor aggressiveness is encouraged by hypoxia, which also lowers patient survival.
Numerous individuals with hypoxic tumors had poor outcomes, which shows that additional …