[HTML][HTML] ACE2: the major cell entry receptor for SARS-CoV-2

F Scialo, A Daniele, F Amato, L Pastore, MG Matera… - Lung, 2020 - Springer
Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus
has infected more than 46 million people worldwide, killing over one million two hundred …

[HTML][HTML] COVID-19 and the elderly: insights into pathogenesis and clinical decision-making

F Perrotta, G Corbi, G Mazzeo, M Boccia… - Aging clinical and …, 2020 - Springer
The elderly may represent a specific cluster of high-risk patients for developing COVID-19
with rapidly progressive clinical deterioration. Indeed, in older individuals …

SARS‐CoV‐2 endothelial infection causes COVID‐19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases

I Colmenero, C Santonja… - British journal of …, 2020 - academic.oup.com
Summary Background Chilblains ('COVID toes') are being seen with increasing frequency in
children and young adults during the COVID‐19 pandemic. Detailed histopathological …

The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer

V Mollica, A Rizzo, F Massari - Future Oncology, 2020 - Future Medicine
The coronavirus disease 2019 (COVID-19) pandemic represents a public health emergency
of international proportions, which is having catastrophic consequences throughout the …

[HTML][HTML] The SARS-coronavirus infection cycle: a survey of viral membrane proteins, their functional interactions and pathogenesis

NA Wong, MH Saier Jr - International journal of molecular sciences, 2021 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a novel epidemic
strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus …

[HTML][HTML] COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside

D Sulzer, A Antonini, V Leta, A Nordvig… - npj Parkinson's …, 2020 - nature.com
This Viewpoint discusses insights from basic science and clinical perspectives on
coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 …

[HTML][HTML] Underlying respiratory diseases, specifically COPD, and smoking are associated with severe COVID-19 outcomes: a systematic review and meta-analysis

DC Sanchez-Ramirez, D Mackey - Respiratory medicine, 2020 - Elsevier
Abstract Background An outbreak of Corona Virus Disease 2019 (COVID-19) has spread
rapidly reaching over 3 million of confirmed cases worldwide. The association of respiratory …

[HTML][HTML] Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients

TW Kragstrup, HS Singh, I Grundberg, ALL Nielsen… - PloS one, 2021 - journals.plos.org
Aims Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin
converting enzyme 2 (ACE2) enabling entrance of the virus into cells and causing the …

[HTML][HTML] Improving target assessment in biomedical research: the GOT-IT recommendations

CH Emmerich, LM Gamboa, MCJ Hofmann… - Nature reviews Drug …, 2021 - nature.com
Academic research plays a key role in identifying new drug targets, including understanding
target biology and links between targets and disease states. To lead to new drugs, however …

[HTML][HTML] What is currently known about the role of CXCL10 in SARS-CoV-2 infection?

M Gudowska-Sawczuk, B Mroczko - International Journal of Molecular …, 2022 - mdpi.com
Dysregulation of the immune response plays an important role in the progression of SARS-
CoV-2 infection. A “cytokine storm”, which is a phenomenon associated with uncontrolled …