In the intricate landscape of the tumor microenvironment, tumor-associated macrophages
(TAMs) emerge as a ubiquitous cellular component that profoundly affects the oncogenic …

Pancreatic cancer is a lethal disease with limited effective treatments. A deeper
understanding of its molecular mechanisms is crucial to reduce incidence and mortality …

HighlightsBacteria and viruses alter the TME pro-or anti-tumorigenic.Metabolic changes in
the TME affect tumor proliferation and metastasis.Engineered bacteria and viruses are …

Pancreatic cancer, one of the deadliest human malignancies, is characterized by a fibro-
inflammatory tumor microenvironment and wide array of metabolic alterations. To …

The tumor microenvironment (TME) is a complex, highly structured, and dynamic ecosystem
that plays a pivotal role in the progression of both primary and metastatic tumors. Precise …

Background Cancer tissues contain a wide variety of immune cells that play critical roles in
suppressing or promoting tumor progression. Macrophages are one of the most …

Tumors growing in metabolically challenged environments, such as glioblastoma in the
brain, are particularly reliant on crosstalk with their tumor microenvironment (TME) to satisfy …

Abstract Backgrounds Homeobox C6 (HOXC6) is a gene that encodes for a transcription
factor involved in various cellular processes, including development and differentiation, and …

Lipid accumulation has recently emerged as a key feature underlying the pro-tumorigenic
role of macrophages. Here, we present a workflow to study macrophage lipid crosstalk with …

Breast cancer is the most frequent cancer in women, with roughly 2.6 million new annual
diagnoses worldwide. Metastases arise in distant tissues such as the lung, liver, and bones …