Osteosarcoma (OS) is the most common primary bone malignancy that affects children and
young adults. OS is characterized by a high degree of malignancy, strong invasiveness …

Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and
immunodeficiency-associated variants. It has been known for many years that the …

Inactivation of the retinoblastoma (RB1) tumor suppressor is one of the most frequent and
early recognized molecular hallmarks of cancer. RB1, although mainly studied for its role in …

Over the last decade, a growing number of tumor suppressor genes have been discovered
to play a role in tumorigenesis. Mutations of p53 have been found in hematological …

Medulloblastoma is the most common malignant tumor of central nervous system in children.
Patients affected by medulloblastoma may be categorized as high-risk and standard-risk …

Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

We investigated the organization of DNA replication sites in primary (young or
presenescent), immortalized and transformed mammalian cells. Four different methods were …

Burkitt lymphoma (BL) is classified into 3 clinical subsets: endemic, sporadic, and
immunodeficiency-associated BL. So far, possible differences in their gene expression …

All Burkitt lymphomas (BLs) carry reciprocal chromosomal translocations that activate the c-
myc oncogene through juxtaposition to one of the immunoglobulin (Ig) loci. Many BL carry …

Burkitt lymphoma (BL), a tumor occurring in endemic, sporadic and AIDS-associated forms,
is the classic example of a human malignancy whose pathogenesis involves a specific …