Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Excitation-contraction coupling (ECC) is a physiological process that links excitation of
muscles by the nervous system to their mechanical contraction. In skeletal muscle, ECC is …

The voltage-gated K+ channel Kv2. 1 serves a major structural role in the soma and
proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to …

Ca V 1.1 is specifically expressed in skeletal muscle where it functions as voltage sensor of
skeletal muscle excitation-contraction (EC) coupling independently of its functions as L-type …

In nerve cells the genes encoding for α2δ subunits of voltage-gated calcium channels have
been linked to synaptic functions and neurological disease. Here we show that α2δ subunits …

In skeletal muscle tissue, an intriguing mechanical coupling exists between two ion
channels from different membranes: the L-type voltage-gated calcium channel (Ca V 1.1) …

T-type calcium channels perform crucial physiological roles across a wide spectrum of
tissues, spanning both neuronal and non-neuronal system. For instance, they serve as …

Voltage-gated calcium channels (VGCCs) are widely expressed in the brain, heart and
vessels, smooth and skeletal muscle, as well as in endocrine cells. VGCCs mediate gene …

Excitation-contraction coupling is the signaling process by which action potentials control
calcium release and consequently the force of muscle contraction. Until recently, three triad …

The pancreatic islets of Langerhans secrete several hormones critical for glucose
homeostasis. The β-cells, the major cellular component of the pancreatic islets, secrete …