Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Metabolic syndrome is a global public health problem and predisposes individuals to
obesity, diabetes and cardiovascular disease. Although the underlying mechanisms remain …

Obesity is one of the main risk factors for type 2 diabetes mellitus (T2DM). It is closely related
to metabolic disturbances in the adipose tissue that primarily functions as a fat reservoir. For …

White adipose tissue is recognized as a dynamic endocrine organ able to produce and
release several bioactive polypeptides known as adipokines. Obesity is defined as an …

Diseases originating from altered energy homeostasis including obesity, and type 2
diabetes are rapidly increasing worldwide. Research in the last few decades on animal …

Global levels of obesity are reaching epidemic proportions, leading to a dramatic increase in
incidence of secondary diseases and the significant economic burden associated with their …

Vaspin (visceral adipose tissue-derived serpin; serpinA12) was originally identified as an
adipokine, which is predominantly secreted from visceral adipose tissue in Otsuka Long …

The discovery of leptin in the 1990s led to a reconsideration of adipose tissue (AT) as not
only a fatty acid storage organ, but also a proper endocrine tissue. AT is indeed capable of …