DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …

The DNA-PK holoenzyme is a fundamental element of the DNA damage response
machinery (DDR), which is responsible for cellular genomic stability. Consequently, and …

Colorectal cancer (CRC) is the third most common carcinoma worldwide. Despite the
progress in screening and treatment, CRC remains a leading cause of cancer-related …

The aim of this study was to evaluate the association and interaction of genotypic
polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and environmental factors …

Background: Hepatocellular carcinoma (HCC) is a neoplasm for which the prevalence and
mortality rates are very high in Taiwan. The DNA non-homologous end-joining repair gene …

Aim: To evaluate the association and interaction among human 8-oxoguanine DNA
glycosylase 1 (hOGG1) genotypic polymorphism, smoking status and lung cancer risk in …

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and is typically
treated with the FOLFOX regimen (folinic acid, 5‐fluorouracil, and oxaliplatin). However …

Over the past few decades, the incidence of cancer has rapidly increased all over the world
and cancer remains a major threat to public health. It is believed that cancer results from a …

Aim: To evaluate the association between the polymorphisms of the ERCC6 DNA repair
gene, which plays an important role in maintaining genome stability, and the risk of bladder …

Background Obesity is one of the main causes of preventable death. Complications of
childhood obesity include cardiovascular risk, impaired glucose tolerance, type 2 diabetes …