The role of the core non-homologous end joining factors in carcinogenesis and cancer
BJ Sishc, AJ Davis - Cancers, 2017 - mdpi.com
DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …
[HTML][HTML] DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions
M Medová, M Medo, L Hovhannisyan… - Pharmacology & …, 2020 - Elsevier
The DNA-PK holoenzyme is a fundamental element of the DNA damage response
machinery (DDR), which is responsible for cellular genomic stability. Consequently, and …
machinery (DDR), which is responsible for cellular genomic stability. Consequently, and …
Association of DNA repair gene polymorphisms with colorectal cancer risk and treatment outcomes
FN Al-Shaheri, KM Al-Shami, EH Gamal… - … and molecular pathology, 2020 - Elsevier
Colorectal cancer (CRC) is the third most common carcinoma worldwide. Despite the
progress in screening and treatment, CRC remains a leading cause of cancer-related …
progress in screening and treatment, CRC remains a leading cause of cancer-related …
Interaction of methylenetetrahydrofolate reductase genotype and smoking habit in Taiwanese lung cancer patients
CS Liu, CW Tsai, TC Hsia, RF Wang… - Cancer Genomics & …, 2009 - cgp.iiarjournals.org
The aim of this study was to evaluate the association and interaction of genotypic
polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and environmental factors …
polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and environmental factors …
The contribution of XRCC6/Ku70 to hepatocellular carcinoma in Taiwan
Background: Hepatocellular carcinoma (HCC) is a neoplasm for which the prevalence and
mortality rates are very high in Taiwan. The DNA non-homologous end-joining repair gene …
mortality rates are very high in Taiwan. The DNA non-homologous end-joining repair gene …
The joint effect of hOGG1 single nucleotide polymorphism and smoking habit on lung cancer in Taiwan
Aim: To evaluate the association and interaction among human 8-oxoguanine DNA
glycosylase 1 (hOGG1) genotypic polymorphism, smoking status and lung cancer risk in …
glycosylase 1 (hOGG1) genotypic polymorphism, smoking status and lung cancer risk in …
SUMO2/3 promotes the progression and oxaliplatin resistance of colorectal cancer through facilitating the SUMOylation at Ku80‐K307
D Feng, J He, M Yuan, Q Chen, X Zeng, Q Zhou… - …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and is typically
treated with the FOLFOX regimen (folinic acid, 5‐fluorouracil, and oxaliplatin). However …
treated with the FOLFOX regimen (folinic acid, 5‐fluorouracil, and oxaliplatin). However …
Role of the XRCC5/XRCC6 dimer in carcinogenesis and pharmacogenomics
Over the past few decades, the incidence of cancer has rapidly increased all over the world
and cancer remains a major threat to public health. It is believed that cancer results from a …
and cancer remains a major threat to public health. It is believed that cancer results from a …
Significant association of ERCC6 single nucleotide polymorphisms with bladder cancer susceptibility in Taiwan
CH Chang, CF Chiu, HC Wang, HC Wu… - Anticancer …, 2009 - ar.iiarjournals.org
Aim: To evaluate the association between the polymorphisms of the ERCC6 DNA repair
gene, which plays an important role in maintaining genome stability, and the risk of bladder …
gene, which plays an important role in maintaining genome stability, and the risk of bladder …
Appearance of acanthosis nigricans may precede obesity: an involvement of the insulin/IGF receptor signaling pathway
Background Obesity is one of the main causes of preventable death. Complications of
childhood obesity include cardiovascular risk, impaired glucose tolerance, type 2 diabetes …
childhood obesity include cardiovascular risk, impaired glucose tolerance, type 2 diabetes …