The introduction of the in vitro evolution method known as SELEX (systematic evolution of
ligands by exponential enrichment) more than 30 years ago led to the conception of …

Serving as the basis of cell life, interactions between nucleic acids and proteins play
essential roles in fundamental cellular processes. Aptamers are unique single-stranded …

Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized
libraries, presenting high affinity and specificity toward targets with similar to antibodies …

Biomarkers are crucial biological indicators in medical diagnostics and therapy. However,
the process of biomarker discovery and validation is hindered by a lack of standardized …

The rapid advancements in nucleic acid-based electrochemical sensors for implantable and
wearable applications have marked a significant leap forward in the domain of personal …

Many applications of machine-learning methods involve an iterative protocol in which data
are collected, a model is trained, and then outputs of that model are used to choose what …

Aptamers are single-stranded DNA or RNA oligonucleotides that can selectively bind to a
specific target. They are generally obtained by SELEX, but the procedure is challenging and …

Conspectus Although antibodies are a powerful tool for molecular biology and clinical
diagnostics, there are many emerging applications for which nucleic acid-based aptamers …

Computational analysis of RNA sequences constitutes a crucial step in the field of RNA
biology. As in other domains of the life sciences, the incorporation of artificial intelligence …

New technologies have provided suitable tools for rapid diagnosis of cancer which can
reduce treatment costs and even increase patients' survival rates. Recently, the …