Probiotics, gut microbiota, and their influence on host health and disease
B Sánchez, S Delgado… - Molecular nutrition & …, 2017 - Wiley Online Library
The gastrointestinal tract of mammals hosts a high and diverse number of different
microorganisms, known as intestinal microbiota. Many probiotics were originally isolated …
microorganisms, known as intestinal microbiota. Many probiotics were originally isolated …
Using genome-scale models to predict biological capabilities
Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have
been under development since the first whole-genome sequences appeared in the mid …
been under development since the first whole-genome sequences appeared in the mid …
[HTML][HTML] Towards bio-upcycling of polyethylene terephthalate
Over 359 million tons of plastics were produced worldwide in 2018, with significant growth
expected in the near future, resulting in the global challenge of end-of-life management. The …
expected in the near future, resulting in the global challenge of end-of-life management. The …
Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v. 3.0
Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic
framework for integrative analysis of experimental molecular systems biology data and …
framework for integrative analysis of experimental molecular systems biology data and …
A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism
Genome-scale metabolic models (GEMs) represent extensive knowledgebases that provide
a platform for model simulations and integrative analysis of omics data. This study …
a platform for model simulations and integrative analysis of omics data. This study …
Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota
Genome-scale metabolic models derived from human gut metagenomic data can be used
as a framework to elucidate how microbial communities modulate human metabolism and …
as a framework to elucidate how microbial communities modulate human metabolism and …
iML1515, a knowledgebase that computes Escherichia coli traits
Figure 1 iML1515 genome-scale reconstruction.(a) The iML1515 model contains 1,515
open reading frames that encode enzymes that catalyze 2,719 reactions involving 1,192 …
open reading frames that encode enzymes that catalyze 2,719 reactions involving 1,192 …
BiGG Models: A platform for integrating, standardizing and sharing genome-scale models
Genome-scale metabolic models are mathematically-structured knowledge bases that can
be used to predict metabolic pathway usage and growth phenotypes. Furthermore, they can …
be used to predict metabolic pathway usage and growth phenotypes. Furthermore, they can …
Improving the phenotype predictions of a yeast genome‐scale metabolic model by incorporating enzymatic constraints
Genome‐scale metabolic models (GEM s) are widely used to calculate metabolic
phenotypes. They rely on defining a set of constraints, the most common of which is that the …
phenotypes. They rely on defining a set of constraints, the most common of which is that the …
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells
The neurovascular unit (NVU) regulates metabolic homeostasis as well as drug
pharmacokinetics and pharmacodynamics in the central nervous system. Metabolic fluxes …
pharmacokinetics and pharmacodynamics in the central nervous system. Metabolic fluxes …