The piperidine ring is an ubiquitous structural feature of many alkaloid natural products and
drug candidates. Watson et al. asserted that during a recent 10-year period there were …

Natural products are embedded with structural motifs that inspire practitioners of synthetic
organic chemistry. The development of new synthetic methods and strategies for the …

The enantio‐and chemoselective iridium‐catalyzed N‐allylation of oximes is described for
the first time. Intramolecular kinetic resolution provides access to cyclic nitrones and …

The synthesis of (±)-histrionicotoxin has been achieved in just nine steps using a two-
directional synthesis strategy. Key reactions include a two-directional cross-metathesis, a …

The total synthesis of the spiropiperidine alkaloid (−)‐perhydrohistrionicotoxin (perhydro‐
HTX) 2 has been accomplished on a gram scale by employing both conventional batch …

Covering: up to June 2006 This article brings together for the first time reviews of all the
synthetic attempts towards the spirocyclic histrionicotoxin alkaloids published since the …

An efficient and general method for 2-and 2, 6-substituted piperidine syntheses using PdII-
catalyzed 1, 3-chirality transfer reaction has been developed. The various N-protected ζ …

A novel method for the stereoselective preparation of 1-azaspiranes is described. Treatment
of α-and β-substituted 3-(methoxyphenyl)-N-methoxypropionamides 1 with phenyliodine (III) …

The related marine natural products halichlorine, pinnaic acid, and tauropinnaic acid have
been synthesized. The described route provided access to all three compounds from a …

3, 3, 3-Trichloropropyl-1-triphenylphosphonium chloride is conveniently prepared from 2-
chloroethanol, triphenylphosphine, and trichloroacetic acid. Deprotonation of this reagent …