The increasing epidemic of obesity worldwide is linked to serious health effects, including
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …

Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

Data demonstrate numerous per-and polyfluoroalkyl substances (PFAS) activate
peroxisome proliferator-activated receptor alpha (PPARα), however, additional work is …

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …

Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor that is abundantly expressed in liver. PPARα is activated by fatty acids and various …

Abstract The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription
factor that plays a major role in metabolic regulation. This review addresses the functional …

Hexafluoropropylene oxide dimer acid (HFPO-DA or GenX) is an industrial replacement for
the straight-chain perfluoroalkyl substance (PFAS), perfluorooctanoic acid (PFOA) …

Nonalcoholic fatty liver disease (NAFLD) encompasses a range of liver pathology ranging
from simple steatosis to varying degrees of inflammation, hepatocyte injury and fibrosis …

The peroxisome proliferator‐activated receptor alpha (PPARα) is a ligand‐activated
transcription factor involved in the regulation of a variety of processes, ranging from …