Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …

The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …

Drug discovery, development and registration is an expensive and time-consuming process
associated with a high failure rate [Pessetto et al.(Mol Cancer Ther 12: 1299–1309, 2013) …

Increasing numbers of DNA structures are being revealed using biophysical, spectroscopic
and genomic methods. The diversity of transition metal complexes is also growing, as the …

Cisplatin and other platinum compounds have had a huge impact in the treatment of cancers
and are applied in the majority of anticancer chemotherapeutic regimens. The success of …

MYCN is amplified in 20% to 25% of neuroblastoma, and MYCN-amplified neuroblastoma
contributes to a large percent of pediatric cancer–related deaths. Therapy improvements for …

Macrophages are one of the principal immune effector cells that play essential roles as
secretory, phagocytic, and antigen-presenting cells in the immune system. In this study, we …

Ofele and Wanzlick reported the synthesis of the first N-heterocyclic carbene (NHC)-metal
complexes in 1968. 1, 2 The isolation of the first free carbene by Arduengo in 1991 set the …