Assessment of right ventricular function in the research setting: knowledge gaps and pathways forward. An Official American Thoracic Society Research Statement
Background: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive
syndromes is a significant determinant of short-and long-term outcomes. Although …
syndromes is a significant determinant of short-and long-term outcomes. Although …
Metabolism in pulmonary hypertension
W Xu, AJ Janocha, SC Erzurum - Annual review of physiology, 2021 - annualreviews.org
Pulmonary arterial hypertension (PAH) is characterized by impaired regulation of pulmonary
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
The metabolic theory of pulmonary arterial hypertension
R Paulin, ED Michelakis - Circulation research, 2014 - Am Heart Assoc
Numerous molecular abnormalities have been described in pulmonary arterial hypertension
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …
Pathobiology of pulmonary arterial hypertension and right ventricular failure
NF Voelkel, J Gomez-Arroyo, A Abbate… - European …, 2012 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is no longer an orphan disease. There are three
different classes of drugs for the treatment of PAH that are currently being used and an …
different classes of drugs for the treatment of PAH that are currently being used and an …
[HTML][HTML] The therapeutic strategies targeting mitochondrial metabolism in cardiovascular disease
Cardiovascular disease (CVD) is a group of systemic disorders threatening human health
with complex pathogenesis, among which mitochondrial energy metabolism reprogramming …
with complex pathogenesis, among which mitochondrial energy metabolism reprogramming …
Mitochondria in the pulmonary vasculature in health and disease: oxygen-sensing, metabolism, and dynamics
In lung vascular cells, mitochondria serve a canonical metabolic role, governing energy
homeostasis. In addition, mitochondria exist in dynamic networks, which serve noncanonical …
homeostasis. In addition, mitochondria exist in dynamic networks, which serve noncanonical …
[HTML][HTML] Pulmonary arterial hypertension treatment with carvedilol for heart failure: a randomized controlled trial
S Farha, D Saygin, MM Park, HI Cheong, K Asosingh… - JCI insight, 2017 - ncbi.nlm.nih.gov
BACKGROUND. Right-sided heart failure is the leading cause of death in pulmonary arterial
hypertension (PAH). Similar to left heart failure, sympathetic overactivation and β …
hypertension (PAH). Similar to left heart failure, sympathetic overactivation and β …
Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and-activation in pulmonary artery smooth muscle cells: implication in pulmonary …
S Chettimada, R Gupte, D Rawat… - … of Physiology-Lung …, 2015 - journals.physiology.org
Severe pulmonary hypertension is a debilitating disease with an alarmingly low 5-yr life
expectancy. Hypoxia, one of the causes of pulmonary hypertension, elicits constriction and …
expectancy. Hypoxia, one of the causes of pulmonary hypertension, elicits constriction and …
Metabolic dysfunction in pulmonary hypertension: from basic science to clinical practice
SY Chan, LJ Rubin - European Respiratory Review, 2017 - Eur Respiratory Soc
Pulmonary hypertension (PH) is an often-fatal vascular disease of unclear molecular origins.
The pulmonary vascular remodelling which occurs in PH is characterised by elevated …
The pulmonary vascular remodelling which occurs in PH is characterised by elevated …
[HTML][HTML] Growing applications of FDG PET-CT imaging in non-oncologic conditions
H Zhuang, I Codreanu - Journal of biomedical research, 2015 - ncbi.nlm.nih.gov
As the number of clinical applications of 2-[fluorine 18] fluoro-2-deoxy-D-glucose (FDG)
positron emission tomography/computed tomography (PET-CT) grows, familiarity with the …
positron emission tomography/computed tomography (PET-CT) grows, familiarity with the …