Over the last 20 years it has become clear that colorectal cancer (CRC) evolves through
multiple pathways. These pathways may be defined on the basis of two molecular …

Despite many studies of the likely survival outcome of individual patients with colorectal
cancer, our knowledge of this subject remains poor. Until recently, we had virtually no …

Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are
collectively mutated in∼ 20% of all human cancers,. Although ARID1A is the most frequent …

Purpose: To compare microsatellite instability (MSI) testing with immunohistochemical (IHC)
detection of hMLH1 and hMSH2 in colorectal cancer. Patients and Methods: Colorectal …

The progress in our understanding of early events in the development of colonic neoplasia
is the result of 2 advances:(1) improved characterization of lesions detected at endoscopy …

The DNA mismatch repair (MMR) system is nec-essary for the maintenance of genomic
stability. In a broad sense, all main functions of the MMR system, including the correction of …

Background and aims: Mutations in BRAF have been linked with colorectal cancers (CRC)
showing high level microsatellite instability (MSI-H). However, the distribution of BRAF …

Molecular classification of colorectal cancer is evolving. As our understanding of colorectal
carcinogenesis improves, we are incorporating new knowledge into the classification …

Cancer with high levels of microsatellite instability (MSI-H) is the hallmark of hereditary
nonpolyposis colorectal cancer syndrome, and MSI-H occurs in∼ 15% of sporadic …

An understanding of the mechanisms that explain the initiation and early evolution of
colorectal cancer should facilitate the development of new approaches to effective …