Classically, aldosterone is synthesised in the adrenal zona glomerulosa and binds to
specific mineralocorticoid receptors located in the cytosol of target epithelial cells …

Aldosterone exerts direct effects on the vascular system by inducing oxidative stress,
inflammation, hypertrophic remodeling, fibrosis, and endothelial dysfunction. Aldosterone …

The renin-angiotensin-aldosterone system (RAAS) is an enzymatic cascade functioning in a
paracrine and autocrine fashion. In animals and humans, RAAS intrinsic to tissues …

The rapid rise in the incidence and prevalence of obesity and the concomitant increase in
the incidence and prevalence of hypertension have fueled investigation into the role of …

The metabolic syndrome associates metabolic abnormalities such as insulin resistance and
dyslipidemia with increased waist circumference and hypertension. It is a major public …

The extremely high sensitivity of polyunsaturated fatty acids (PUFAs) to oxygen is apparently
used by nature to induce stepwise appropriate cell responses. It is hypothesized that any …

In the past decades, we have extended the view of aldosterone effects beyond epithelial
tissues. New evidence regarding the aldosterone/mineralocorticoid receptor (MR) pathway …

Endocannabinoids (eCBs) are products of phospholipid (PL)-derived arachidonic acid (AA)
that regulate hypothalamus-pituitary-adrenal axis activity. We hypothesized that differences …

For half a century, Seymour Levine's pioneering work on the interactions between mother
and infant have helped us understand the critical early factors that shape physiology and …

Although salt is a major environmental factor in the development of hypertension, the degree
of salt sensitivity varies widely among individuals. The mechanisms responsible for this …