The kelch motif was discovered as a sixfold tandem element in the sequence of the
Drosophila kelch ORF1 protein. The repeated kelch motifs predict a conserved tertiary …

Kelch-like gene family members (KLHLs) encode proteins with a bric-a-brac, tramtrack,
broad complex (BTB)/poxvirus and zinc finger (POZ) domain, a BACK domain, and six Kelch …

Background Soft-tissue tumours are derived from mesenchymal cells such as fibroblasts,
muscle cells, or adipocytes, but for many such tumours the histogenesis is controversial. We …

Disorganization of the neurofilament network is a prominent feature of several
neurodegenerative disorders including amyotrophic lateral sclerosis (ALS), infantile spinal …

Transforming growth factor β (TGF-β) increases epithelial cancer cell migration and
metastasis by inducing epithelial-mesenchymal transition (EMT). TGF-β also inhibits cell …

Pituitary adenomas (PAs) can be classified as non-secreting adenomas, somatotroph
adenomas, corticotroph adenomas, lactotroph adenomas, and thyrotroph adenomas …

Background The kelch motif is an ancient and evolutionarily-widespread sequence motif of
44–56 amino acids in length. It occurs as five to seven repeats that form a β-propeller tertiary …

Retinoic acid (RA), the biologically active derivative of vitamin A, induces a variety of
embryonal carcinoma and neuroblastoma cell lines to differentiate into neurons. The …

We identified a testis-specific gene encoding a protein containing a BTB/POZ domain and
six kelch repeats, which we named kel ch h omo l og 10 (KLHL10). KLHL10 displays high …

Background Extracting biological knowledge from large amounts of gene expression
information deposited in public databases is a major challenge of the postgenomic era …