G protein-coupled receptors (GPCRs) are capable of interacting to form higher order
structures such as homomers and heteromers. Heteromerisation in particular has …

Prostaglandin (PG) receptors represent important druggable targets due to the many diverse
actions of PGs in the body. From an ocular perspective, the discovery, development, and …

Objective We assessed the spatiotemporal GLP-1 and GIP receptor signaling, trafficking,
and recycling dynamics of GIPR mono-agonists, GLP-1R mono-agonists including …

In conjunction with the endothelin (ET) type A (ETAR) and type B (ETBR) receptors,
angiotensin (AT) type 1 (AT1R) and type 2 (AT2R) receptors, are peptide-binding class A G …

Objectives Scleroderma renal crisis (SRC) is a rare vascular complication of systemic
sclerosis with substantial risks for end-stage renal disease and premature death. Activating …

Introduction Preterm birth is one of the major causes of neonatal morbidity and mortality
across the world. Both term and preterm labour are preceded by inflammatory activation in …

Receptor heteromerization is the formation of a complex involving at least two different
receptors with pharmacology that is distinct from that exhibited by its constituent receptor …

The mechanical response of the heart to myocardial stretch has been understood since the
work of muscle physiologists more than 100 years ago, whereby an increase in ventricular …

As the largest family of cell surface receptors, G protein-coupled receptors (GPCRs)
represent an important strategic class of therapeutic targets. Attaining a clearer perspective …

The vascular endothelium is the innermost layer of blood vessels and is a key regulator of
vascular tone. Endothelial function is controlled by receptor signaling through G protein …