Nuclear factor-kappa B and its role in inflammatory lung disease

KS Alharbi, NK Fuloria, S Fuloria, SB Rahman… - Chemico-biological …, 2021 - Elsevier
Nuclear factor-kappa B, involved in inflammation, host immune response, cell adhesion,
growth signals, cell proliferation, cell differentiation, and apoptosis defense, is a dimeric …

Perivascular inflammation in pulmonary arterial hypertension

Y Hu, L Chi, WM Kuebler, NM Goldenberg - Cells, 2020 - mdpi.com
Perivascular inflammation is a prominent pathologic feature in most animal models of
pulmonary hypertension (PH) as well as in pulmonary arterial hypertension (PAH) patients …

Immunity and inflammation in pulmonary arterial hypertension: from pathophysiology mechanisms to treatment perspective

R Wang, T Yuan, J Wang, Y Chen, J Zhao, M Li… - Pharmacological …, 2022 - Elsevier
Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary dysfunctional disease,
characterized by progressive vascular remodeling. Inflammation is an increasingly …

The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes

SC Pugliese, JM Poth, MA Fini… - … of Physiology-Lung …, 2015 - journals.physiology.org
Hypoxic pulmonary hypertension (PH) comprises a heterogeneous group of diseases
sharing the common feature of chronic hypoxia-induced pulmonary vascular remodeling …

Pulmonary hypertension: Linking inflammation and pulmonary arterial stiffening

SF Liu, N Nambiar Veetil, Q Li… - Frontiers in …, 2022 - frontiersin.org
Pulmonary hypertension (PH) is a progressive disease that arises from multiple etiologies
and ultimately leads to right heart failure as the predominant cause of morbidity and …

Sulforaphane attenuates muscle inflammation in dystrophin-deficient mdx mice via NF-E2-related factor 2 (Nrf2)-mediated inhibition of NF-κB signaling pathway

CC Sun, SJ Li, CL Yang, RL Xue, YY Xi, L Wang… - Journal of Biological …, 2015 - ASBMB
Inflammation is widely distributed in patients with Duchenne muscular dystrophy and
ultimately leads to progressive deterioration of muscle function with chronic muscle damage …

New drugs and therapies in pulmonary arterial hypertension

AJ Shah, T Beckmann, M Vorla, DK Kalra - International Journal of …, 2023 - mdpi.com
Pulmonary arterial hypertension is a chronic, progressive disorder of the pulmonary
vasculature with associated pulmonary and cardiac remodeling. PAH was a uniformly fatal …

Adaptation and remodelling of the pulmonary circulation in pulmonary hypertension

M Vaillancourt, G Ruffenach, J Meloche… - Canadian Journal of …, 2015 - Elsevier
Pulmonary arterial hypertension (PAH) is characterized by remodelling of pulmonary
arteries caused by a proliferation/apoptosis imbalance within the vascular wall. This …

Nuclear IL-33 regulates soluble ST2 receptor and IL-6 expression in primary human arterial endothelial cells and is decreased in idiopathic pulmonary arterial …

D Shao, F Perros, G Caramori, C Meng… - Biochemical and …, 2014 - Elsevier
Idiopathic pulmonary arterial hypertension (IPAH) is an incurable condition leading to right
ventricular failure and death and inflammation is postulated to be associated with vascular …

Crosstalk between the Akt/mTORC1 and NF-κB signaling pathways promotes hypoxia-induced pulmonary hypertension by increasing DPP4 expression in PASMCs

Y Li, L Yang, L Dong, Z Yang, J Zhang… - Acta Pharmacologica …, 2019 - nature.com
Abnormal wound healing by pulmonary artery smooth muscle cells (PASMCs) promotes
vascular remodeling in hypoxia-induced pulmonary hypertension (HPH). Increasing …