[HTML][HTML] IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting
L Broderick, HM Hoffman - Nature Reviews Rheumatology, 2022 - nature.com
Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …
monogenic disorders characterized by recurrent fever and systemic inflammation. The …
[HTML][HTML] The pyrin inflammasome in health and disease
The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …
[HTML][HTML] Metabolic induction of trained immunity through the mevalonate pathway
Innate immune cells can develop long-term memory after stimulation by microbial products
during infections or vaccinations. Here, we report that metabolic signals can induce trained …
during infections or vaccinations. Here, we report that metabolic signals can induce trained …
Classification criteria for autoinflammatory recurrent fevers
M Gattorno, M Hofer, S Federici, F Vanoni… - Annals of the …, 2019 - ard.bmj.com
Background Different diagnostic and classification criteria are available for hereditary
recurrent fevers (HRF)—familial Mediterranean fever (FMF), tumour necrosis factor receptor …
recurrent fevers (HRF)—familial Mediterranean fever (FMF), tumour necrosis factor receptor …
The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation
Autoinflammatory diseases were first recognized nearly 20 years ago as distinct clinical and
immunological entities caused by dysregulation in the innate immune system. Since then …
immunological entities caused by dysregulation in the innate immune system. Since then …
Caspase functions in cell death and disease
DR McIlwain, T Berger, TW Mak - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Caspases are a family of endoproteases that provide critical links in cell regulatory networks
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …
Points of control in inflammation
C Nathan - Nature, 2002 - nature.com
Inflammation is a complex set of interactions among soluble factors and cells that can arise
in any tissue in response to traumatic, infectious, post-ischaemic, toxic or autoimmune injury …
in any tissue in response to traumatic, infectious, post-ischaemic, toxic or autoimmune injury …
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome
HM Hoffman, JL Mueller, DH Broide, AA Wanderer… - Nature …, 2001 - nature.com
Familial cold autoinflammatory syndrome (FCAS, MIM 120100), commonly known as familial
cold urticaria (FCU), is an autosomal-dominant systemic inflammatory disease characterized …
cold urticaria (FCU), is an autosomal-dominant systemic inflammatory disease characterized …
Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
SL Masters, A Simon, I Aksentijevich… - Annual review of …, 2009 - annualreviews.org
The autoinflammatory diseases are characterized by seemingly unprovoked episodes of
inflammation, without high-titer autoantibodies or antigen-specific T cells. The concept was …
inflammation, without high-titer autoantibodies or antigen-specific T cells. The concept was …
Mevalonate pathway: a review of clinical and therapeutical implications
I Buhaescu, H Izzedine - Clinical biochemistry, 2007 - Elsevier
Mevalonate pathway is an important metabolic pathway which plays a key role in multiple
cellular processes by synthesizing sterol isoprenoids, such as cholesterol, and non-sterol …
cellular processes by synthesizing sterol isoprenoids, such as cholesterol, and non-sterol …