Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

Autophagy is a complicated cellular mechanism that maintains cellular and tissue
homeostasis and integrity via degradation of senescent, defective subcellular organelles …

Aim Imbalance of T-helper-cell (TH) subsets (TH1/TH2/TH17) and regulatory T-cells (Tregs)
is suggested to contribute to the pathogenesis of Systemic lupus erythematosus (SLE) …

Interleukin‐12 family cytokines have emerged as critical regulators of immunity with some
members (IL‐12, IL‐23) associated with disease pathogenesis while others (IL‐27, IL‐35) …

Lupus nephritis (LN), a potentially destructive outcome of SLE, is a real challenge in the
management of SLE because of the difficulty in diagnosing its subclinical onset and …

Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and
hyperreactivity of the immune response at various levels, including hyperactivation of …

Regulatory T cells (Tregs) represent a cell type that promotes immune tolerance to
autologous components and maintains immune system homeostasis. The abnormal function …

The mechanistic target of rapamycin (mTOR) is activated in CD4− CD8− double-negative
(DN) T cells and its blockade is therapeutic in systemic lupus erythematosus (SLE) patients …

Systemic lupus erythematosus (SLE) is the prototypical autoimmune disease that can affect
any organ of the body. Multiple mechanisms may contribute to the pathophysiology of …

Th17 cells are a distinct lineage of T-cells. These T-cells express IL-17A and the lineage-
defining transcription factor RORγt. Th17 cells have a pivotal, physiological role in host …