The human genome is organized into multiple structural layers, ranging from chromosome
territories to progressively smaller substructures, such as topologically associating domains …

Age-related macular degeneration (AMD) is the leading cause of severe irreversible central
vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) …

The impact of variations in the three-dimensional structure of the genome has been
recognized, but solid cancer tissue studies are limited. Here, we performed integrated deep …

To spread from a localized tumor, metastatic cancer cells must squeeze through
constrictions that cause major nuclear deformations. Since chromosome structure affects …

Cancer arises following alterations at different cellular levels, including genetic and
epigenetic modifications, transcription and translation dysregulation, as well as metabolic …

Chromosomes inside the nucleus are not located in the form of linear molecules. Instead,
there is a complex multilevel genome folding that includes nucleosomes packaging …

Genome-wide association studies along with expression quantitative trait locus (eQTL)
mapping have identified hundreds of single-nucleotide polymorphisms (SNPs) and their …

Extracellular matrix (ECM) stiffness is a major driver of stem cell fate. However, the
involvement of the three-dimensional (3D) genomic reorganization in response to ECM …

Epigenetic modifiers are upregulated during the process of prostate cancer, acquiring
resistance to castration therapy and becoming lethal metastatic castration-resistant prostate …

Wilms tumors present as an amalgam of varying proportions of tissues located within the
developing kidney, one being the nephrogenic blastema comprising multipotent nephron …