Non-coding RNAs in human disease
M Esteller - Nature reviews genetics, 2011 - nature.com
The relevance of the non-coding genome to human disease has mainly been studied in the
context of the widespread disruption of microRNA (miRNA) expression and function that is …
context of the widespread disruption of microRNA (miRNA) expression and function that is …
MicroRNA functions in stress responses
AKL Leung, PA Sharp - Molecular cell, 2010 - cell.com
MicroRNAs (miRNAs) are a class of∼ 22 nucleotide short noncoding RNAs that play key
roles in fundamental cellular processes, including how cells respond to changes in …
roles in fundamental cellular processes, including how cells respond to changes in …
MicroRNAs in neuronal function and dysfunction
MicroRNAs (miRNAs) are small noncoding RNA transcripts expressed throughout the brain
that can regulate neuronal gene expression at the post-transcriptional level. Here, we …
that can regulate neuronal gene expression at the post-transcriptional level. Here, we …
MicroRNA therapeutics: the next magic bullet?
B Simonson, S Das - Mini reviews in medicinal chemistry, 2015 - ingentaconnect.com
MicroRNAs are short noncoding 18-25 nucleotide long RNA which bind and inhibit mRNA.
Currently, there are over 1000 known human microRNAs, and microRNAs control over 50 …
Currently, there are over 1000 known human microRNAs, and microRNAs control over 50 …
[HTML][HTML] Small interfering RNA for cancer treatment: overcoming hurdles in delivery
In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug
delivery systems are based on the difference between cancer and healthy cells. Currently …
delivery systems are based on the difference between cancer and healthy cells. Currently …
MicroRNAs as novel biological targets for detection and regulation
MicroRNAs are being considered as a novel type of bio-markers and potential therapeutic
targets for various diseases. Diverse chemical tools are being developed for the detection or …
targets for various diseases. Diverse chemical tools are being developed for the detection or …
[HTML][HTML] Dysregulation of microRNAs in cancer: playing with fire
SA Melo, M Esteller - FEBS letters, 2011 - Elsevier
MicroRNAs [1] have emerged as key post-transcriptional regulators of gene expression,
involved in various physiological and pathological processes. It was found that several …
involved in various physiological and pathological processes. It was found that several …
[HTML][HTML] Repositioning of fluoroquinolones from antibiotic to anti-cancer agents: An underestimated truth
Increasing development costs and higher failure rate in clinical trials has reduced the
repertoire of newer drugs in the market for clinical use. The most appropriate approach to …
repertoire of newer drugs in the market for clinical use. The most appropriate approach to …
Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids
YP Xu, Y Qiu, B Zhang, G Chen, Q Chen, M Wang… - Cell research, 2019 - nature.com
The re-emergence of Zika virus (ZIKV) in the Western Hemisphere has resulted in global
public health crisis since 2015. ZIKV preferentially infects and targets human neural …
public health crisis since 2015. ZIKV preferentially infects and targets human neural …
Dysregulated mi RNA biogenesis downstream of cellular stress and ALS‐causing mutations: a new mechanism for ALS
Interest in RNA dysfunction in amyotrophic lateral sclerosis (ALS) recently aroused upon
discovering causative mutations in RNA‐binding protein genes. Here, we show that …
discovering causative mutations in RNA‐binding protein genes. Here, we show that …