The remarkable complexity of globular protein structures was first revealed about half a
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …

The final goal of functional genomics is to determine the biological role for all of the genes in
a cell. At present, the genome-scale prediction of protein function is based primarily on the …

A comparative analysis of the main-chain conformation of the L1, L2, L3, H1 and H2
hypervariable regions in 17 immunoglobulin structures that have been accurately …

We describe a suite of programs, PROMOTIF, that analyzes a protein coordinate file and
provides details about the structural motifs in the protein. The program currently analyzes the …

Compartmentalization is an important organizational feature of life. It occurs at varying levels
of complexity ranging from eukaryotic organelles and the bacterial microcompartments, to …

The structure of yeast iso-1-cytochrome c has been refined against X-ray diffraction data to a
nominal resolution of 1.23 A˚. The atomic model contains 893 protein atoms, as well as 116 …

We have examined the intramolecular hydrogen bonding behavior of simple ß-and-amino
acid derivatives as a prelude to efforts to design unnatural polyamides that will adopt …

The three-dimensional structure of wild-type CheY from Escherichia coli has been refined by
stereochemically restrained least squares minimization to a crystallographic R-factor of …

High-throughput genomic sequencing has focused attention on understanding differences
between species and between individuals. When this genetic variation affects protein …

Conformational clusters and consensus sequences for protein loops have been derived by
computational analysis of their structures in a non-redundant set of 233 proteins with less …