This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …

The rodent infralimbic cortex (IL) is implicated in higher order executive functions such as
reward seeking and flexible decision making. However, the precise nature of its role in these …

Drug addiction is a chronic relapsing disorder, and a significant amount of research has
been devoted to understand the factors that contribute to the development, loss of control …

The medial prefrontal cortex (mPFC) drives cocaine‐seeking behaviour in rodent models of
cocaine use disorder. Parvalbumin (PV)‐containing GABAergic interneurons powerfully …

Prior evidence indicates that the infralimbic cortex (IL) mediates the ongoing inhibition of
cocaine seeking following self-administration and extinction training in rats, specifically …

Persistent susceptibility to cue-induced relapse is a cardinal feature of addiction.
Discriminative stimuli (DSs) are one type of drug-associated cue that signal drug availability …

Methamphetamine (meth) causes enduring changes within the medial prefrontal cortex
(mPFC) and the nucleus accumbens (NA). Projections from the mPFC to the NA have a …

The capacity to suppress learned responses is essential for animals to adapt in dynamic
environments. Extinction is a process by which animals learn to suppress conditioned …

A large body of research supports the notion that regions of the rodent frontal cortex regulate
reinstatement of cocaine seeking after cessation of intravenous cocaine self-administration …

Reciprocal pathways connecting the cerebellum to the prefrontal cortex provide a biological
and functional substrate to modulate cognitive functions. Dysfunction of both medial …