It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …

Neurological disease and disorders remain a large public health threat. Thus, research to
improve early detection and/or develop more effective treatment approaches are necessary …

Protein palmitoylation is the post-translational, reversible addition of a 16-carbon fatty acid,
palmitate, to proteins. Protein palmitoylation has recently garnered much attention, as it …

Mass spectrometry imaging (MSI) is able to simultaneously record the distributions of
hundreds of molecules directly from tissue. Rapid direct tissue analysis is essential for MSI …

Female middle age is characterized by a decline in skeletal muscle mass and performance,
predisposing women to sarcopenia, functional limitations, and metabolic dysfunction as they …

The NCLs (neuronal ceroid lipofuscinosis) are forms of neurodegenerative disease that
affect people of all ages and ethnicities but are most prevalent in children. Commonly known …

The heart of a newborn mouse has an exceptional capacity to regenerate from myocardial
injury that is lost within the first week of its life. In order to elucidate the molecular …

Treatments are emerging for the neuronal ceroid lipofuscinoses (NCLs), a group of similar
but genetically distinct lysosomal storage diseases. Clinical ratings scales measure long …

CLN5 disease is a rare form of late-infantile neuronal ceroid lipofuscinosis (NCL) caused by
mutations in the CLN5 gene that encodes a protein whose primary function and …

Endocrine tumors derive from endocrine cells with high heterogeneity in function, structure
and embryology, and are characteristic of a marked diversity and tissue heterogeneity …