ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting
motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5 …

In the fatal disease—amyotrophic lateral sclerosis (ALS)—upper (corticospinal) motor
neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate …

Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …

Melatonin is known to possess several properties of value for healthy aging, as a direct and
indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease presenting as sporadic
(sALS) or familial (fALS) forms. Even if the list of the genes underlining ALS greatly …

Age is associated with increased risk for several disorders including dementias,
cardiovascular disease, atherosclerosis, obesity, and diabetes. Age is also associated with …

Amyotrophic lateral sclerosis (ALS) is an incurable and fatal disorder characterized by the
progressive loss of motor neurons in the cerebral cortex, brain stem, and spinal cord …

Mutations in fused in sarcoma (FUS) are linked to amyotrophic lateral sclerosis (ALS), a fatal
neurodegenerative disease affecting both upper and lower motor neurons. While it is …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which motor neurons
throughout the brain and spinal cord progressively degenerate resulting in muscle atrophy …