Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The
enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl …

Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …

Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

[Avena, NM, Rada, P., Hoebel BG, 2007. Evidence for sugar addiction: Behavioral and
neurochemical effects of intermittent, excessive sugar intake. Neuroscience and …

Release of the neurotransmitter dopamine in the mesolimbic system of the brain mediates
the reinforcing properties of several drugs of abuse, including nicotine. Here we investigate …

In this review we will critically assess the hypothesis that the reinforcing effect of virtually all
drugs of abuse is primarily dependent on activation of the mesolimbic dopamine system …

Reactivity to smoking-related cues may be an important factor that precipitates relapse in
smokers who are trying to quit. The neurobiology of smoking cue reactivity has been …

Rationale This review provides insight for the judicious selection of nicotine dose ranges
and routes of administration for in vivo studies. The literature is replete with reports in which …

Nicotinic ACh (nACh) receptors in the CNS are composed of a diverse array of subunits and
have a range of pharmacological properties. However, despite the fact that they are ligand …

Epidemiological and clinical data indicate high comorbidity between depression and drug
dependence that may reflect an attempt to self-medicate with drugs of abuse. The present …