Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling

M Chandy, D Obal, JC Wu - EMBO Molecular Medicine, 2022 - embopress.org
Induced pluripotent stem cells (iPSCs) are a powerful modeling system for medical
discovery and translational research. To date, most studies have focused on the potential for …

[HTML][HTML] Organoids and organoids-on-a-chip as the new testing strategies for environmental toxicology-applications & advantages

C Hu, S Yang, T Zhang, Y Ge, Z Chen, J Zhang… - Environment …, 2024 - Elsevier
An increasing number of harmful environmental factors are causing serious impacts on
human health, and there is an urgent need to accurately identify the toxic effects and …

Microplastics exposure affects neural development of human pluripotent stem cell-derived cortical spheroids

T Hua, S Kiran, Y Li, QXA Sang - Journal of Hazardous Materials, 2022 - Elsevier
Plastics have been part of our ecosystem for about a century and their degradation by
different environmental factors produce secondary microplastics (MPs). To date, the impact …

[HTML][HTML] Application of organoid technology in the human health risk assessment of microplastics: A review of progresses and challenges

J Cong, J Wu, Y Fang, J Wang, X Kong, L Wang… - Environment …, 2024 - Elsevier
Microplastic (MP) pollution has become a global environmental issue, and increasing
concern has been raised about its impact on human health. Current studies on the toxic …

Application of a genetically engineered macrophage cell line for evaluating cellular effects of UV/US-treated poly (ethylene terephthalate) microplastics

N Washihira, M Murakami, M Nakamura, S Fujii… - Colloids and Surfaces B …, 2024 - Elsevier
Microplastic (MP) pollution is a global environmental problem. To understand the biological
effects of MPs on humans, it is essential to evaluate the response of human cells to model …

Human-Organoid-Based In Vitro Modeling for Environmental Toxicology

E Kwak, G Peng - Environmental Science & Technology Letters, 2024 - ACS Publications
Environmental pollutants pose significant health risks and elevate the likelihood of
developing diseases. Organoid-based models offer the potential to transform environmental …

Genome-engineering technologies for modeling and treatment of cystic fibrosis

M Dębczyński, D Mojsak, Ł Minarowski… - Advances in Medical …, 2023 - Elsevier
Cystic fibrosis (CF) is an autosomal recessive disease caused by defects in the CF
transmembrane conductance regulator (CFTR) protein. Due to the genetic nature of the …

[HTML][HTML] A Comprehensive Review on Zebrafish and Zebrafish Embryonic Stem Cells (Zescs) as the Versatile Biotechnological Green Tool for Detecting …

J Nellore - Biosciences Biotechnology Research Asia, 2023 - biotech-asia.org
This article discusses the embryonic development of zebrafish, which are essential aquatic
models for investigating neurotoxicity caused by environmental toxins. Zebrafish are one of …