A forced degradation study is an essential step in the design of a regulatory compliant
stability program for both drug substances and products, and was formalized as a regulatory …

Computational chemistry applications have become an integral part of the drug discovery
workflow over the past 35 years. However, computational modeling in support of drug …

Purpose Chemical degradation and stability in formulation is a recurrent issue in
pharmaceutical development of drugs. The objective of the present study was to develop an …

ABSTRACT A method to predict a compound's sensitivity toward autoxidation using bond
dissociation energies for hydrogen abstraction is described. The methodology is based on …

Gauging the chemical stability of active pharmaceutical ingredients (APIs) is critical at
various stages of pharmaceutical development to identify potential risks from drug …

The C–H bond dissociation energy (BDE) of drug molecules is often used to estimate their
relative propensities to undergo autoxidation. BDE calculations based on electronic …

The analytical technologies currently in use for profiling degradation-related impurities
(DRI's) are powerful, but not without their limitations. This article critically assesses the …

Drug stability and degradation studies are integral parts of drug development.
Preformulation studies aim to evaluate the intrinsic stability properties of a drug candidate by …

Zeneth is a new software application capable of predicting degradation products derived
from small molecule active pharmaceutical ingredients. This study was aimed at …

The present study aimed to investigate methods for accelerating autoxidation of crystalline
drugs in the solid-state that can potentially predict real− time stability. Solid droperidol (DPD) …