This document reviews 1) the measurement properties of commonly used exercise tests in
patients with chronic respiratory diseases and 2) published studies on their utilty and/or …

Abundant data from animal models and humans support the hypothesis that changes at the
level of parasympathetic neuronal control of airway smooth muscle result in increased …

Endobronchial valve placement improves pulmonary function in some patients with chronic
obstructive pulmonary disease, but its effects on exercise physiology have not been …

The present review summarizes the current knowledge of the cholinergic systems in the
airways with special emphasis on the role of acetylcholine both as neurotransmitter in …

METHODS The FLOW study is an ongoing prospective cohort study of adults recruited from
the membership of an integrated health care delivery system. 11, 12 All subjects carry a …

Background The endurance shuttle walking test (ESWT) has shown good responsiveness to
interventions in patients with chronic obstructive pulmonary disease (COPD). However, the …

Background Although exercise capacity is an important outcome measure in patients with
COPD, its longitudinal course has not been analyzed in comparison to the change in …

CONTEXT: Activity limitation and dyspnea are the dominant symptoms of chronic obstructive
pulmonary disease (COPD). Traditionally, efforts to alleviate these symptoms have focused …

Exercise intolerance is a key element in the pathophysiology and course of Chronic
Obstructive Pulmonary Disease (COPD). As such, evaluating exercise tolerance has …

Background: Patients with symptoms of GOLD stage I chronic obstructive pulmonary disease
(COPD) can have significant abnormalities of ventilatory mechanics with greater exertional …