Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …

Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene
regulation and encompass the well-known microRNAs (miRNAs), as well as the most …

Diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal
prognosis despite current best therapies; therefore new treatment strategies are urgently …

Elucidating the spectrum of epithelial-mesenchymal transition (EMT) and mesenchymal-
epithelial transition (MET) states in clinical samples promises insights on cancer progression …

One of the hallmarks of the tumour microenvironment is hypoxia resulting from increased
oxygen consumption by proliferative cancer cells and altered vasculature. Hypoxic tension …

FRA1 (FOSL1) is a transcription factor and a member of the activator protein-1 superfamily.
FRA1 is expressed in most tissues at low levels, and its expression is robustly induced in …

Epithelial-mesenchymal plasticity (EMP) contributes to tumor progression, promoting
therapy resistance and immune cell evasion. Definitive molecular features of this plasticity …

Natural killer (NK) cells are innate lymphocytes that play a major role in immunosurveillance
against tumor initiation and metastatic spread. The signals and checkpoints that regulate NK …

Epithelial–mesenchymal transition (EMT) is prominent in circulating tumor cells (CTC), but
how it influences metastatic spread in this setting is obscure. Insofar as blood provides a …

Hypoxia is a feature of the microenvironment of many cancers and can trigger epithelial-
mesenchymal transition (EMT), a process by which cells acquire a more invasive phenotype …