Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The ability of a cell to undergo mitochondrial apoptosis is governed by pro-and anti-
apoptotic members of the BCL-2 protein family. The equilibrium of pro-versus anti-apoptotic …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

The ability of cancer cells to suppress apoptosis is critical for carcinogenesis. The BCL2
family proteins comprise the sentinel network that regulates the mitochondrial or intrinsic …

BCL-2 family proteins, which have either pro-or anti-apoptotic activities, have been studied
intensively for the past decade owing to their importance in the regulation of apoptosis …

Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic
BH3-only proteins via interaction of its BH3 domain with a groove on the Bcl-2-like proteins …

Apoptosis, the cell-suicide programme executed by caspases, is critical for maintaining
tissue homeostasis, and impaired apoptosis is now recognized to be a key step in …

In multicellular organisms, the total number of cells is a balance between the cell-generating
effects of mitosis and cell death that is induced through apoptosis. A disruption of this …

The anti‐apoptotic proteins Bcl‐2 and Bcl‐XL bind and inhibit Beclin‐1, an essential
mediator of autophagy. Here, we demonstrate that this interaction involves a BH3 domain …

Apoptotic cells are commonly observed in a broad range of tissues during mammalian
embryonic and fetal development. Specific requirements and functions of programmed cell …