Cardiotoxicity is the main concern for long‐term use of the doxorubicin (DOX). Reactive
oxygen species (ROS) generation leads to oxidative stress that significantly contributes to …

In addition to the anti-diabetic effect of metformin, a growing number of studies have shown
that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer …

Long-term cardiovascular complications of cancer therapy are becoming ever more
prevalent due to increased numbers of cancer survivors. Cancer therapy-induced …

Mitochondria are organelles that play a pivotal role in the production of energy in cells, and
vital to the maintenance of cellular homeostasis due to the regulation of many biochemical …

Ferritin, an iron-storage protein, regulates cellular iron metabolism and oxidative stress. The
ferritin structure is characterized as a spherical cage, inside which large amounts of iron are …

Cardiotoxicity is the major side effect of anthracyclines (doxorubicin, daunorubicin,
epirubicin, and idarubicin), though being the most commonly used chemotherapy drugs and …

A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Female breast cancer is the most deadly cancer in women worldwide. The triple-negative
breast cancer subtype therapies, due to the lack of specific drug targets, are still based on …

Doxorubicin (DOX) is a potent antitumor agent with a broad spectrum of activity; however,
irreversible cardiotoxicity resulting from DOX treatment is a major issue that limits its …

Abstract Background and Objective Breast cancer patients treated with adriamycin-
cyclophosphamide plus paclitaxel (AC-T) are often challenged with serious adverse effects …