During hyperinflammatory conditions that can occur in acute critical illness, such as shock or
hypoperfusion, inflammatory mediators activate the endothelium, fueling a proinflammatory …

Junction dynamics of endothelial cells are based on the integration of signal transduction,
cytoskeletal remodeling and contraction, which are necessary for the formation and …

The zebrafish heart regenerates after ventricular damage through a process involving
inflammation, fibrotic tissue deposition/removal and myocardial regeneration. Using 3D …

Blood vessels are constantly exposed to shear stress, a biomechanical force generated by
blood flow. Normal shear stress sensing and barrier function are crucial for vascular …

Although several tissues and chemokines orchestrate coronary formation, the guidance
cues for coronary growth remain unclear. Here, we profile the juvenile zebrafish epicardium …

Purpose: Vitronectin, a cell adhesion and spreading factor, is suspected to play a role in the
pathogenesis of age-related macular degeneration (AMD), as it is a major component of …

Cellular senescence is one type of permeant arrest of cell growth and one of increasingly
recognized contributor to aging and age-associated disease. High phosphate and low …

Abstract Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is
constitutively produced by endothelial cells and plays a vital role in maintaining vascular …

Plasminogen activator inhibitor type 1 (PAI-1) is the main physiologic inhibitor of fibrinolysis.
However, it is also involved in many physiological processes such as extracellular matrix …

While several effective therapies for critically ill patients with COVID-19 have been identified
in large, well-conducted trials, the mechanisms underlying these therapies have not been …