Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …

Vulnerability to relapse during periods of attempted abstinence from cocaine use is
hypothesized to result from the rewiring of brain reward circuitries, particularly ventral …

Although it is challenging for individuals with cocaine addiction to achieve abstinence, the
greatest difficulty is avoiding relapse to drug taking, which is often triggered by cues …

Understanding the brain circuitry that underlies reward is critical to improve treatment for
many common health issues, including obesity, depression, and addiction. Here we focus …

The nucleus accumbens is a key mediator of cocaine reward, but the distinct roles of the two
subpopulations of nucleus accumbens projection neurons, those expressing dopamine D1 …

While stressful life events are an important cause of psychopathology, most individuals
exposed to adversity maintain normal psychological functioning. The molecular mechanisms …

OBJECTIVE: A primary behavioral pathology in drug addiction is the overpowering
motivational strength and decreased ability to control the desire to obtain drugs. In this …

Mice experiencing repeated aggression develop a long-lasting aversion to social contact,
which can be normalized by chronic, but not acute, administration of antidepressant. Using …

It was suggested in 1986 that cue-induced drug craving in cocaine addicts progressively
increases over the first several weeks of abstinence and remains high for extended periods …